Immune Regulators in Crohn’s disease
Immune Regulators in Crohn’s disease
Principal Investigator:
Andrew Stadnyk, PhD
Division of Gastroenterology, Department of Pediatrics
IWK Health Centre and Dalhousie University
Study sponsors:
W. Garfield Weston Foundation
Purpose: Using our cohort of young patients with Crohn’s disease (CD) who were being treated with nutritional therapy, we have identified an important role of a bacterial protein protein and its interaction with the innate immune system. The goal of this project is to determine the role of the protein that is produced by human intestinal bacteria. Using a cross-disciplinary approach spanning from computational biology to molecular and cellular immunology, we will develop computational and experimental frameworks to determine the biological properties of the protein in order to optimize its use an immune regulator in the treatment of CD.
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